Author

Raquel Martínez-López

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Open access Sep 2026

Thirty years of fluconazole therapy selects an azole-resistant Candida albicans isolate with a pre-adapted physiological, metabolic and structural state

Azole resistance in Candida albicans is traditionally attributed to alterations in drug targets and efflux mechanisms; however, how long-term antifungal exposure reshapes fungal physiology remains incompletely understood. Here, we characterize a fluconazole-resistant C. albicans clinical isolate (PUJ256) recovered from...

C. Parra-Giraldo, Julio Jesús Estrada-Valbuena, Yerly Vargas-Casanova et al. · bioRxiv · 0 citations

Open access Sep 2026

Bioprospecting Soil Microorganisms as a Source of Antimicrobial Compounds Active Against ESKAPE Pathogens

The escalating global crisis of antimicrobial resistance (AMR), particularly among the ESKAPE group, necessitates the discovery of novel therapeutic agents. Soil ecosystems represent a vast, under‐explored repository of microbial secondary metabolites with potent antimicrobial properties. This study aimed to identi...

Julio Jesús Estrada-Valbuena, Cristina Vico-Uribes, Alejandro Fernández-Vega et al. · Medicine Bulletin · 0 citations