Open access
Oct 2026
Aging Affects Pancreatic α‐Cell Function and Promotes Hyperglucagonemia: Implications in Age‐Associated Diabetes
ABSTRACT Aging is a major risk factor in the development of type 2 diabetes mellitus (T2DM). With age, pancreatic β‐cells undergo functional and cell identity changes that can compromise insulin secretion, thereby contributing to impaired glucose tolerance and T2DM. However, glucose homeostasis also depends on pancreat...
E. Tudurí, Lucía Almagro, Ana Ojeda-Rodríguez et al.
· Aging Cell · 0 citations