Author

Rasangi Tennakoon

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Open access Sep 2026

A Metabolic Labeling Strategy for Tracking Protein Synthesis in Complex Biological Systems

Protein synthesis supports most biological processes. In the brain in particular, protein synthesis plays a critical role in physiological and pathological states. Here, we describe Tellurophene-Alkyne Cycloaddition-mediated Amino acid Tagging (TeACAT), a versatile strategy for fast, facile, and flexible tagging of new...

Yong Bu, Samuel P. Nyandwi, F. de Lima Alves et al. · bioRxiv · 0 citations

Aug 2026

Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis.

This work combined site-specific chemical modification of sup-tRNAs with cargo-tailored pulmonary lipid nanoparticle (LNP) engineering to overcome barriers and restore cystic fibrosis transmembrane conductance regulator (CFTR) expression and function.

Jin-Gan Chen, Mu-Ye Zhou, Song-Tao Dong et al. · Science · 2 citations