Rasha Ghanem Kattoub

New Class of Uridine- and Adenosine-Based Morpholino Nucleosides as Potential Anti-SARS-CoV-2 Agents: Synthesis, Antiviral Evaluation, Molecular Modeling, and In Silico ADMET Properties

A novel library of 38 fused bicyclic morpholino-uridine and -adenosine derivatives was constructed through an innovative, single-step strategy based on a reductive aminocyclization reaction between readily prepared nucleoside secodialdehydes and bifunctional amines, emphasizing the potential of this fused bicyclic syst...