Circular RNAs (circRNAs) are endogenous, covalently closed RNA molecules generated through back-splicing that exhibit exceptional stability, evolutionary conservation, tissue-specific expression and diverse regulatory functions. Compared with conventional RNA-based therapeutic platforms, such as messenger RNAs (mRNAs),...
Niranjan Kumar, Chainsee Saini, Rashi Soni et al.· Frontiers in Pharmacology· 0 citations
An integrated view of MELK dysregulation in LUAD is provided, linking its G2/M-associated activity with post-transcriptional regulation, immune features, and potential therapeutic targeting.
Kritika Jangir, Niranjan Kumar, Chainsee Saini et al.· Frontiers in Oncology· 0 citations
A comprehensive perspective on MELK is offered that stands out in the existing literature for its critical evaluation of context-dependent functions and therapeutic relevance and highlights key gaps that must be addressed to establish MELK as a reliable cancer biomarker and therapeutic target.
Kritika Jangir, Prachi Patidar, Bhavika Baweja et al.· Frontiers in Oncology· 0 citations
This review consolidates current knowledge of TTK function beyond its canonical SAC activity, emphasizing its emerging roles in DNA damage response, epithelial-mesenchymal transition, and oncogenic signaling pathways.
Prachi Patidar, Kritika Jangir, Chainsee Saini et al.· Cell Communication and Signa...· 0 citations
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