Rasmus Linser

Mapping of dynamic allostery within p38 alpha kinase via network analyses and NMR spectroscopy

Dynamical network analysis is used to identify key residues involved in a dynamic allostery between the N- and C-lobes that connects the major functional units of the MAP kinase p38α, providing mechanistic insight into p38α allostery and suggesting viable opportunities for the rational design of allosteric modulators o...