Phosphatidylinositol 3-Kinase Alpha in Breast Cancer Stem Cells: Insights from Structure Prediction and Molecular Dynamics
B. Saputra, Navista Sri, Octa Ujiantari et al.
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Open access
Sep 2026
α-Chaconine as a Potential Inhibitor of Mutant Phosphatidylinositol 3-Kinase Alpha in Breast Cancer Stem Cells: Insights from Structure Prediction and Molecular Dynamics.
INTRODUCTION Breast cancer stem cells (BCSCs) promote chemoresistance and metastasis by activating aberrant signaling pathways such as phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt). α-Chaconine (CHA) is a steroidal glycoalkaloid that has demonstrated cytotoxic and antiproliferative activity in various cance...
B. Saputra, N. Ujiantari, Badra Sanditya Rattyananda et al.
· Asian Pacific Journal of Can... · 0 citations