Raul Urrutia

Multiple simulated spaceflight stressors impact cardiac fibrosis, calcium dynamics, immune function, cytokines and gene variants in rat, Rattus norvegicus

Space radiation and microgravity pose significant health risks for astronauts conducting deep space exploration. The impact of galactic cosmic radiation (GCR) and weightlessness alone, and their combined effects on cardiac disease, the immune system, cytokines and calcium dynamics should be understood before undertakin...

Interpreting human genetic variation at atomic resolution.

Stress granules confer an early vulnerability in KRAS-driven pancreatic tumorigenesis.

It is shown that stress granules (SGs) formation is a key adaptive mechanism enabling pancreatic cells to tolerate oncogenic KRAS signaling, and SGs inhibition does not affect pancreatic damage during chronic pancreatitis, supporting its safety for selectively targeting KRAS-mutant cells.