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Raviraj Shetty

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Review Open access Jul 2026

Comprehensive Review of the Architectural Metamorphosis and Techno-Economic Implications of Artificial Intelligence-Integrated Digital Twin Ecosystems

Digital twin (DT) technology has emerged as a cornerstone of Industry 4.0, facilitating real-time synchronization between physical assets and virtual models to drive operational excellence. Unlike prior surveys that address singular industrial domains, presenting qualifications in general terms without paradigm-to-task mapping, this review uniquely synthesizes DT architectural maturation across Technology Readiness Levels (TRLs) 1 through 9, quantitative performance outcomes from 39 documented industrial implementations spanning 10 sectors, and an explicit algorithmic taxonomy mapping distinct AI paradigms to specific functional DT requirements. By synthesizing empirical data across the aerospace, automotive, and manufacturing sectors, this study evaluates the quantitative impact of DT implementation, highlighting significant gains in predictive maintenance, production efficiency, and design cycle reduction. This research further examines the synergistic role of Machine Learning (ML) paradigms integrated within DT systems, specifically, physics-informed neural networks (PINNS), generative adversarial networks (GANs), deep transfer learning, reinforcement learning, and federated learning, in enhancing diagnostic accuracy and enabling autonomous decision-making. Despite these advancements, this review identifies critical barriers in data interoperability, cybersecurity, and workforce expertise that impede widespread adoption. This paper concludes by outlining future research directions, emphasizing the necessity for standardized data protocols and secure, distributed DT ecosystems to unlock the full potential of cyber-physical integration in a data-driven industrial landscape.

Adithya Hegde, Raviraj Shetty, Vinyas et al. · 0 citations
Review Open access Jul 2026

Electrospun nanofibers as postsurgical microenvironment modulators for functional tissue repair

The postoperative microenvironment is a highly biologically dynamic environment that is associated with an increased risk of complications, including adhesions, fibrosis, infection, and delayed healing, which can cause significant inconvenience to patients. Conventional materials, such as cotton gauze and surgical sutures, primarily function as passive physical barriers, often lacking to address the multiple issues governing functional tissue repair. Electrospun nanofibers have been effective as dynamic regulators of the post-surgical microenvironment, facilitating simultaneous modulation of key biological events, such as immune modulation, macrophage phenotype switching, angiogenesis, collagen organization, and tissue regeneration, leading to faster and better healing. Overall, this review aims to provide a focused and mechanistic perspective on electrospun nanofibers as multifunctional, bioactive scaffolds capable of enabling functional tissue regeneration rather than merely serving as passive wound dressing and nominate it as a sustainable alternative for developing next-generation smart scaffolds intended for postsurgical healing.

Animita Das, K. Chethan, N. Shetty et al. · 0 citations