Author

Rebecca M. Richards

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Open access Sep 2026

Low-dose radiopharmaceutical therapy enhances the efficacy of B7-H3 CAR T cells in murine metastatic neuroblastoma

Background Chimeric antigen receptor (CAR) T cell therapy has had clinical success in hematologic malignancies, but limited efficacy is seen in solid tumors. In this study, we investigated whether systemic CAR T cell therapy could be enhanced in metastatic models of neuroblastoma when combined with radiopharmaceutical...

A. Shea, Andy S. Ollendorff, Andreanna Wilke et al. · bioRxiv · 0 citations

Open access Aug 2026

Disruption of the interferon-gamma axis limits chimeric antigen receptor T cell efficacy against acute myeloid leukemia

It is demonstrated that disruption of the IFNγ axis impedes anti-AML CAR T cell function and prevents upregulation of target antigen CD123, the apoptotic mediator Fas, and the adhesion molecule ICAM-1 on AML cells.

Nat Murren, Isaac King, Lauren Mahoney et al. · bioRxiv · 0 citations