Reena Rajkumari

Large-scale virtual screening of 17,967 IMPPAT phytochemicals identifies multiple CDR1 binders and reveals Apigenin-7-O-glucuronide as a putative CDR1-GSC1 dual-target lead against Candida albicans with initial in-vitro evidence

The increasing incidence of antifungal resistance in Candida albicans, mainly mediated by multidrug efflux transporters and alterations of cell-wall biosynthesis, requires the discovery of new antifungal compounds targeting multiple pathways involved in resistance. In the present study, we employed an integrated comput...