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Author

Reinier Hernandez

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2 papers indexed here

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Open access Sep 2026

Low-dose radiopharmaceutical therapy enhances the efficacy of B7-H3 CAR T cells in murine metastatic neuroblastoma

Background Chimeric antigen receptor (CAR) T cell therapy has had clinical success in hematologic malignancies, but limited efficacy is seen in solid tumors. In this study, we investigated whether systemic CAR T cell therapy could be enhanced in metastatic models of neuroblastoma when combined with radiopharmaceutical...

A. Shea, Andy S. Ollendorff, Andreanna Wilke et al. · 0 citations
Open access Jul 2026

Cancer vaccine in combination with radiopharmaceutical therapy (RPT) upregulates type I interferon pathway in Ovalbumin-expressing tumor model 2254330

To enhance the efficacy of therapeutic cancer vaccines, combination strategies are needed to overcome mechanisms of immunoresistance. RPT, such as pan-cancer targeting 90Y-NM600, can act as an immunomodulating agent. We have previously found that cancer vaccines administered prior to RPT elicited greater anti-tum...

Daeun Shim, Colette Mouton, Jena E. Moseman et al. · 0 citations

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