Aug 2026
Simultaneous determination of bosutinib and its metabolite in rat plasma by UPLC-MS/MS: Development, validation and application to pharmacokinetic and metabolic stability studies.
In vivo pharmacokinetic studies confirmed that the UPLC-MS/MS method could be successfully used for the analysis of bosutinib after oral administration of 50 mg/kg in rats, and provides a potential reference for the clinical investigation of bosutinib.
Pei-Qi Wang, Yan Chen, Jun Wu et al.
· Chemico-Biological Interacti... · 0 citations