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Ren-Chao Zheng

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Aug 2026

Dynamically Coupled Network-Guided Engineering of Amine Dehydrogenase With Cofactor Recycling for Efficient Biosynthesis of (R)-3-Aminobutanol.

(R)-3-Aminobutanol is a valuable chiral amino alcohol widely used in the pharmaceutical industry. The amine dehydrogenase (AmDH)-catalyzed synthesis with inorganic ammonia as the amine donor represents one of the most promising routes for its production. However, this approach is limited by the low catalytic efficiency...

Teng‐Kun Huang, Cen Huang, Du Wu et al. · 0 citations
Jul 2026

Construction of a Self-Assembled Multi-Enzyme Cascade for Efficient D-Allulose Biosynthesis.

d-Allulose is a valuable low-calorie rare sugar with diverse physiological benefits. Although phosphorylation-dephosphorylation-based multi-enzyme cascades enable efficient d-allulose biosynthesis, the free-enzyme format limits substrate channeling and promotes intermediate diffusion, resulting in byproduct accumulatio...

Zhe-Ming Wu, Yu Lu, Jin-Chao Zhang et al. · 0 citations

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