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Author

Renjing Lin

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Jul 2026

Naringenin from Citrus aurantium L. alleviates loperamide-induced constipation by inhibiting excessive autophagy-mediated apoptosis in interstitial cells of Cajal via the AKT1 signaling pathway.

It is demonstrated that naringenin alleviates constipation by targeting the AKT1 signaling pathway to inhibit excessive autophagy-induced apoptosis and oxidative stress in ICCs, providing a scientific basis for the traditional use of CAL.

Ren-Jing Lin, Ying Nie, Yong-Heng He et al. · 0 citations

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