Open access
Oct 2026
Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer‐related mortality. Integrative multi‐omics and machine‐learning analyses across independent cohorts identified CYYR1 as a frequently downregulated transmembrane protein in LUAD, with low expression associated with poor prognosis and promoter hypermet...
Feng-Sheng Dai, Jing-Yi Tang, Huan Rong et al.
· Advancement of science · 0 citations