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Aug 2026

Beyond random splits: A hierarchical benchmark of transferability and reliability in PROTAC activity prediction.

A hierarchical benchmark designed to expose evaluation pitfalls and quantify the transferability and reliability limits of current PROTAC predictors is presented, repositioning PROTAC prediction as a problem of transferability and reliability rather than leaderboard optimization and provide practical guidelines for fut...

Ren Zhu, Guang-Hao Guo, Lu-Lu Li et al. · 0 citations

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