Open access
Aug 2026
Kinase-specific phosphorylation of tau outside the amyloid core encodes fibril fold selection
It is demonstrated that kinase-specific phosphorylation outside the amyloid core can be sufficient to bias tau toward a defined fibril structure, establishing a direct mechanistic link between kinase specificity, post-translational modification, and tau strain formation.
Reshma Ramesh, Sambhasan Banerjee, Madhu Babu Gajula Balija et al.
· bioRxiv · 0 citations