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Author

Reuben Opoku

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Review Open access Aug 2026

Biofilm-Associated Immune Vulnerability in Streptococcus pneumoniae: Virulence-Factor Remodeling and Therapeutic Implications for Invasive Disease

Streptococcus pneumoniae biofilms contribute to persistent carriage, immune evasion, and progression to invasive disease. Recent studies indicate that the biofilm state alters the display and function of key surface-associated virulence factors, including PspA, PspC, and LytA, and may reduce susceptibility to complemen...

Reuben Opoku, Isaac Nana Kissi Darko · 0 citations
Review Open access Aug 2026

Targeting host adaptation in Streptococcus pneumoniae: A narrative review of biological strategies beyond antibiotics

Streptococcus pneumoniae remains a leading cause of severe respiratory disease in U.S. adults despite expanded conjugate vaccination and guideline-directed antibiotic therapy. Rising antimicrobial resistance, serotype replacement, and rapid within‑host evolutionary adaptation collectively undermine the long‑term effect...

Reuben Opoku · 0 citations

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