Immunotherapeutic Strategies Targeting Amyloid-β and Tau in Alzheimer’s Disease: A Systematic Review of Clinical Efficacy, Safety, and Translational Limitations
Alzheimer’s disease (AD) is one of the leading neurodegenerative disorders affecting over 55 million individuals worldwide, with a limited selection of disease-modifying therapies. The amyloid cascade hypothesis proposes that amyloid-beta (Aβ) peptide accumulation initiates a cascade of synaptic dysfunction, neuroinfla...