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Author

Rhys H. Parry

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Open access Sep 2026

Proteolytic control of the SARS-CoV-2 furin cleavage site defines the phenotypic evolution from the pandemic to endemic state

The successive emergence of SARS-CoV-2 variants with altered tissue tropism has progressively decoupled transmissibility from lower respiratory tract pathogenicity. Omicron lineages transmit exceptionally well whilst limiting severe lung disease. Here, we demonstrate that this phenotype has evolved through two temporal...

A. Aggarwal, S. Ognenovska, Timothy Ison et al. · 0 citations
Open access Sep 2026

sRNAMap: a lightweight, browser-based web application for small RNA mapping, analysis and visualisation

Small RNA (sRNA) sequencing is widely used to study siRNA, miRNA and piRNA pathways and to profile sRNAs derived from viruses, transposons and host transcripts. However, many sRNA workflows rely on command-line mapping and separate software for downstream analysis and visualisation. We present sRNAMap, an HTML5/JavaScr...

M. Reuter, Lachlan de Hayr, Christopher Chong Wei Ang et al. · 0 citations
Open access Aug 2026

Expanding Reverse Genetics of Positive-Strand RNA Viruses: Optimised Rescue Platforms and Construction of a Novel Fluorescent Reporter Nidovirus

It is demonstrated that a potent constitutive promoter system and a hammerhead ribozyme enhance the efficiency of positive-sense RNA virus rescue using CPER, and may support applications requiring efficient recovery of low fitness mutants and diverse mutational libraries and barcoded virus populations.

James R. Potter, Helen Mostafavi, A. Amarilla et al. · 0 citations
Open access Aug 2026

Leishmania guyanensis controls endogenous viral replication by a canonical RNA interference pathway

This study investigated effectors in the canonical RNAi response and the Piwi protein of the human pathogen L. (Viannia) guyanensis by gene ablation and identified Dicer-like and Argonaute 1 proteins of the canonical RNAi pathway as critical for controlling viral RNA levels, suggesting that control of viral replication...

Donnamae Klocek, Rhys H. Parry, G. A. Kay et al. · 0 citations

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