Author

Rhyston Broadhurst

2 papers indexed here

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Open access Oct 2026

Targeting SERPINB5 and MSLN for Pancreatic Cancer Therapy

Simple Summary Pancreatic cancer (PC) is a leading cause of cancer-related death, with no effective therapy for curing late-stage PC. Developing effective therapeutic strategies is an emergent unmet need. SERPINB5 is non-inhibitory toward serine proteases, and mesothelin (MSLN) is a tumor-associated antigen. SERPINB5 a...

Jing-Hui Sun, Ling-Ling Liu, Rhyston Broadhurst et al. · Cancers · 0 citations

Open access Jul 2026

The Missense Mutant ClC-5 (E211A), associated with Proton/Chloride Uncoupling Exacerbates Renal Pathology Compared to the ClC-5 null Mutant.

The results reveal that uncoupling mutations can drive progressive kidney damage through mechanisms distinct from gene knockout and highlight the need for mutation-specific therapeutic strategies for Dent disease type 1.

Aykut Bostancı, Pin Lyu, Cuili Jiang et al. · Kidney360 · 0 citations