Open access
Aug 2026
Identification of methylation-sensitive human transcription factors using meSMiLE-seq
Transcription factors (TFs) are key players in eukaryotic gene regulation, but the DNA binding specificity of many TFs remains unknown. Here, we assay 284 mostly uncharacterized putative human TFs using selective microfluidics-based ligand enrichment followed by sequencing (SMiLE-seq), revealing 74 new DNA binding moti...
Antoni J. Gralak, Kateřina Faltejsková, Ally W. H. Yang et al.
· Nature Communications · 2 citations