Author

Richard Border

2 papers indexed here

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Open access Oct 2026

Integration of single cell omics with biobank data discovers allele-specific trans effects of SREBF1 on adipocyte expression of nearly 100 genes

Given the high global prevalence of obesity and lack of mechanistic, cell-type level knowledge of regulatory genes predisposing obesity, it would be critical to improve our understanding of how gene expression profiles are regulated in trans in adipocytes, the main cell-type in subcutaneous adipose tissue (SA...

M. G. Sukhatme, A. Kar, Seung Hyuk T. Lee et al. · Genome Medicine · 0 citations

Open access Aug 2026

Inferring Protein Variant Impacts Across Contexts

It is found that which method is optimal depends on the imputation task and on how densely the contexts have been measured, with more flexible models excelling when measurements are plentiful and the simplest models proving most reliable when measurements are sparse.

Alireza Rasoulzadeh, Vignesh Senguttuvan, W. van Loggerenberg et al. · bioRxiv · 0 citations