Image-guided low-intensity focused ultrasound neuromodulation: acoustic targeting optimization and functional validation in a reward circuit model.
OBJECTIVE To develop and validate an ultrasound-guided low-intensity focused ultrasound (USg-LIFU) platform for subject-specific deep-brain neuromodulation and test whether ventral tegmental area (VTA) targeting modulates alcohol-related behaviour in a mouse model of alcohol use disorder. METHODS USg-LIFU uses ultras...