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Author

Richard D. Braatz

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Open access Sep 2026

Process Analytical Technology (PAT) for Continuous Purification of mRNA via Precipitation and Tangential Flow Filtration.

Continuous downstream processing of messenger ribonucleic acid (mRNA) therapeutics requires purification strategies that are scalable, robust, and capable of removing product- and process-related impurities from in vitro transcription mixtures. Precipitation-based purification coupled with tangential flow filtration (T...

Rajan R. Bhawnani, Maria del Carme Pons Royo, Rohan P. Kadambi et al. · 0 citations
Preprint Sep 2026

Integrated Population Balance and Multiphysics Modeling for Predicting Undesired Agglomeration in Small Molecule Manufacturing

Agitated filter dryers (AFDs) are a crucial unit operation in small molecule manufacturing that enables simultaneous filtration, washing, and drying of active pharmaceutical ingredients. One of the key challenges in AFDs is associated with undesired agglomeration, where the presence of hard agglomerates results in off-...

Prakitr Srisuma, Peter Hou, S. Muddu et al. · 0 citations
Preprint Aug 2026

Nonadaptive Learning in Robust Nonlinear Output Regulation

A nonadaptive design that combines an input-driven filter and a generic internal model with a recursive backstepping law is developed, thereby recasting the regulation problem as the robust input-to-state stabilization of an augmented error system.

Shi-Min Wang, M. Guay, Richard D. Braatz · 0 citations

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