Author

Richard J. Payne

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Sep 2026

Precision Protein Modification via Ligation and Bioconjugation at Selenocysteine

Selenocysteine (Sec), often referred to as the 21st amino acid, is a rare yet essential amino acid found in a small number of naturally occurring selenoproteins that play critical roles in redox regulation, antioxidant defence, and hormone metabolism. Owing to its distinct chemical properties, namely enhanced nucleop...

Max J. Bedding, Sameer S. Kulkarni, Richard J. Payne · Accounts of Chemical Researc... · 0 citations

Open access Aug 2026

Development of macrocyclic peptide inhibitors of Mycobacterium tuberculosis MurF via mRNA display with genetic reprogramming.

The development of new antibacterials for Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains critical due to the continued global burden of disease and the emergence of multi-drug resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains. The MurF enzyme, which catalyses the AT...

Patrick W. Carlos, Charlotte Franck, Caitlin E. Clarke-Shepperson et al. · RSC Medicinal Chemistry · 0 citations