Author

Richard J. Perrin

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Open access Jul 2026

Ms4a4a loss reprograms amyloid-associated microglia and limits dense-core plaque-associated tau spreading

INTRODUCTION Microglia regulate amyloid plaque-associated microenvironments that contribute to downstream tau pathology in Alzheimer’s disease (AD). Variants within the MS4A locus are strongly associated with AD risk and resilience and are linked to microglial biology; however, the functional role of MS4A4A in plaque-a...

E. Danhash, Shao-Yu Fang, Jacob A. Marsh et al. · bioRxiv · 0 citations

Open access Jul 2026

Remote digital cognitive assessment in a trial‐ready Alzheimer's disease cohort: A scalable approach for early intervention studies

ABSTRACT INTRODUCTION Early detection of cognitive decline in Alzheimer's disease (AD), particularly in preclinical stages, is critical for evaluating therapeutic interventions. Traditional cognitive assessments often require lengthy in‐person visits, and may therefore limit scalability for younger, trial‐ready populat...

A. Aschenbrenner, H. Wilks, Matthew S. Welhaf et al. · Alzheimer's & Dementia · 1 citation