Background/Objectives: Seasonal influenza threatens global public health through rapid mutations. This study evaluated the prevalence and molecular-genetic characteristics of seasonal influenza viruses circulating in Kazakhstan during the 2023–2026 epidemic seasons. Methods: Nasopharyngeal swabs (n = 1756) and serum sa...
N. Klivleyeva, T. Glebova, A. Baimukhametova et al.· Viruses· 0 citations
The continued emergence of genetically diverse high pathogenicity avian influenza (HPAI) H5N1 viruses with zoonotic potential highlights the urgent need for developing vaccines capable of providing broad protection against multiple circulating clades. Here, we developed a one-shot, multivalent, live-attenuated influenz...
Ahmed M. Elsayed, Ramya S. Barre, Arash Rahmani et al.· bioRxiv· 0 citations
Self-amplifying mRNA (samRNA) vaccines can induce potent immune responses at lower doses than conventional non-replicating mRNA vaccines; however, large RNA size and manufacturing considerations associated with 5' capping remain important challenges. Here, we developed a capless samRNA (CLsamRNA) vaccine platform deriv...
Beom Kyu Kim, Ji-Hyun Park, Won-Suk Choi et al.· Molecular Therapy· 0 citations
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