Author

Richard M. Cubbon

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Review Open access Aug 2026

Clonal hematopoiesis of indeterminate potential (CHIP), vascular somatic mutation, and cardiovascular disease: A narrative review

Somatic cell DNA mutations accumulate with age, and can give cells a survival advantage, resulting in their clonal expansion over time. We know that these mutations can lead to cancer, but the growing application of next-generation sequencing across multiple ‘healthy’ tissues has revealed their ubiquity and relevance t...

N. Powell, Richard M. Cubbon, M. A. Bailey et al. · Vascular Medicine · 0 citations

Open access Aug 2026

The metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis

Exercise orchestrates an interorgan communication network, in which skeletal muscle releases signaling molecules known as myokines that contribute to exercise training-induced adaptations. We identified the muscle-derived metabolite beta-aminoisobutyric acid (BAIBA) as a regulator of adipose and hepatic metabolic respo...

H. Daou, N. Watt, Shaimaa A. Gad et al. · Nature Communications · 0 citations