Open access
Aug 2026
FoxO transcription factors coordinate the urea cycle and gluconeogenesis by controlling Ass1
A KLF15-independent FoxO-Ass1 axis that coordinates ureagenesis with gluconeogenesis during fasting and supports hepatic metabolic adaptation to nutrient deprivation is established.
S. Karkoutly, Yoshinori Takeuchi, Zahra Mehrazad Saber et al.
· iScience · 0 citations