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Author

Riley J. Mangan

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Open access Sep 2026

Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humans.

Through multiplex, single-cell enhancer assays, HAQERs are identified as active enhancers in the developing brain and cardiomyocytes, and their potential contributions to human-specific gene regulation across multiple tissues are highlighted.

Yan-Ting Luo, Riley J. Mangan, S. Weaver et al. · 0 citations
Open access Aug 2026

Sequence-to-function deep learning decodes human cis-regulatory evolution

Deciphering the regulatory consequences of sequence divergence across human evolution is essential to understanding the molecular basis of human-specific traits and disease. Although millions of derived alleles distinguish humans from great apes, only a small fraction are likely to influence human-specific traits. Prev...

Riley J. Mangan, Nikitha Thoduguli, Dimitar Ivanov et al. · 0 citations

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