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Second-Course Reirradiation Versus No Reirradiation in Pediatric Diffuse Intrinsic Pontine Glioma: A Meta-Analysis of Survival Outcomes.
BACKGROUND Diffuse intrinsic pontine glioma (DIPG) presents in 1-2 cases per million children annually. Upfront radiation therapy (RT) is the only proven treatment for DIPG despite which relapse is common. Survival benefits of reirradiation (reRT) have been studied priorly in a smaller, single-arm meta-analysis, but ou...