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Author

Riri Hayashi

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2 papers indexed here

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Open access Aug 2026

Cotinine Enhances Androgen Receptor Stability and Promotes Androgen-Dependent Proliferation in Prostate Cancer Cells: An In Vitro Study.

Cigarette smoking is associated with a poor prognosis and reduced efficacy of androgen receptor signaling inhibitors (ARSIs) in prostate cancer patients; however, the underlying molecular mechanisms remain largely undefined. This study investigated the impact of cotinine, the stable primary metabolite of nicotine, on a...

Riri Hayashi, Yudai Kudo, Yuta Yoshino et al. · 0 citations
Sep 2026

Upamostat potentiates bortezomib cytotoxicity and delays proteasome recovery in bortezomib-resistant malignant lymphoma cells through modulation of the DDI2/NRF1 axis.

Proteasome inhibitors such as bortezomib (BTZ) are potent against hematological malignancies, but acquired resistance remains a major obstacle to durable clinical responses. DNA damage-inducible 1 homolog 2 (DDI2)-mediated processing of nuclear factor erythroid 2-related factor 1 (NRF1) contributes to adaptive proteaso...

Atsumi Ota, Sota Maruyama, Yudai Kudo et al. · 0 citations

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