Ririn Rahamala Febri

Ligand-dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry.

ErbB ligands activate distinct receptor dimers that regulate cell proliferation, but how they influence cell-cycle commitment remains unclear. Here, we show that EGF and HRG induce different modes of G1/S progression in ErbB2-amplified BT474 breast cancer cells. Unexpectedly, HRG, despite activating the more potent Erb...