Design, Synthesis, Biological Studies and Putative Binding Mode of Novel Benzotriazolothalidomide Derivatives as Cereblon Ligands
Targeted protein degradation (TPD) represents a new paradigm in drug discovery, encompassing several innovative strategies like proteolysis targeting chimeras (PROTACs). PROTACs work by linking the target protein of interest (POI) to an E3 ubiquitin ligase, marking it for ubiquitination, and subsequent degradation by t...