Open access
Aug 2026
Anchoring of perforin-2 via the transmembrane domain is required for antigen escape into the cytosol
Perforin-2 is a pore-forming protein localised to the endocytic compartments of dendritic cells and macrophages. It is reported to perform two distinct functions during immune responses: attacking intravacuolar pathogens, and forming pores in endocytic compartments to enable cytosolic delivery of antigens during cross-...
Marco Laub, Ritika Chatterjee, Patrycja Kozik
· EMBO Journal · 0 citations