Dictyostelium discoideum is a genetically tractable amoebozoan model organism widely used to study conserved eukaryotic cellular processes, yet a comprehensive map of its subcellular proteome has been lacking. Here, we combined subcellular fractionation with label-free mass spectrometry to resolve a global protein loca...
Statton Tinker, Yu-Ping Poh, Katarzyna Dąbrowska et al.· bioRxiv· 0 citations
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are linked neurodegenerative diseases characterized by both synaptic dysfunction and TDP-43 pathology. A hexanucleotide repeat expansion (HRE) in the C9ORF72 (C9) gene represents the most common genetic cause of FTD and ALS, yet the synapse-specific...
A. Spillman, E. Alsop, L. M. Gittings et al.· Acta Neuropathologica· 0 citations
It is demonstrated that a single tDR coordinates cell-type-specific protective programs in the heart, suggesting a new therapeutic axis to mitigate HF progression.
Tian Hao, Jin Li, Kaushik V. Amancherla et al.· bioRxiv· 0 citations
Combined multi-omic profiling of synaptosomes enriched from postmortem frontal cortex and patient-derived induced pluripotent stem cell (iPSC)-derived cortical neurons defines convergent molecular pathways underlying synapse vulnerability in both C9-FTD model systems and identifies synaptic localization of CE-containin...
A. Spillman, E. Alsop, L. M. Gittings et al.· bioRxiv· 0 citations
This work developed an integrated experimental and computational pipeline for protein-level cell annotation and applied it to human PBMCs as an immune-cell test case, delivering an analytically benchmarked SCP workflow that resolves immune lineage and cell-state heterogeneity in human PBMCs and provides a classifier-re...
S. O'Connor, Romell B. Gletten, Ritin Sharma et al.· bioRxiv· 1 citation
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