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Author

Robert A. Richardson

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Open access Aug 2026

Intranasal delivery of a COBRA-based protein vaccine adjuvanted with c-di-AMP enhances breadth of protective immune responses against seasonal influenza viruses

Seasonal influenza vaccines provide variable protection against antigenically drifted influenza A (H1N1 and H3N2) and influenza B viruses. Broadly protective approaches using computationally optimized broadly reactive antigens (COBRAs) can enhance immunity against diverse strains. Bis-(3′,5′)-cyclic dimeric adenosine m...

Camila C. S. Caetano, David A. Prots, Matthew H. Thomas et al. · 0 citations

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