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Author

Robert A. Rissman

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2 papers indexed here

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Open access Sep 2026

Cell type-specific histone acetylation landscape in Alzheimer’s disease reveals a putative role of MITF in microglia

Alzheimer’s disease (AD) is characterised by aberrant amyloid beta and tau aggregation, neuroinflammation, demyelination and neurodegeneration, which have been linked to changes in cell-specific gene expression signatures. Among the mechanisms driving cell-type-specific transcriptional changes, histone acetylation play...

Charbel Gergian, Paulina Urbanaviciute, Philippa M. Wells et al. · 0 citations
Open access Sep 2026

Plasma Biomarker Effects of Oral Valiltramiprosate/ALZ-801 in Early Alzheimer’s Disease from Phase 3 and Phase 2 Trials: Analysis of Core Biomarkers and Correlations with Clinical and Neuroimaging Outcomes

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with few treatment options, especially for APOE4/4 homozygotes who carry high genetic risk. Valiltramiprosate/ALZ-801 is an oral small-molecule inhibitor of amyloid-beta oligomer formation in late-stage development as a disease-modifying therapy for A...

J. Hey, S. Abushakra, A. Power et al. · 0 citations

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