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Author

Robert D. Schreiber

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Clinical trial Open access Sep 2026

Synthetic long peptide and DNA personalized cancer vaccines induce robust neoantigen-specific T cell responses in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is unresponsive to standard immunotherapies despite harboring cancer neoantigens capable of eliciting T cell responses. We completed two phase 1 clinical trials (NCT03956056 and NCT03122106) evaluating safety and immunogenicity of synthetic long peptide (SLP) and DNA personalized...

Felicia Zhang Perkins, Xiu-Li Zhang, Y. Yu et al. · 0 citations
Open access Aug 2026

Personalized Neoantigen Vaccines Synergize with Immune Checkpoint Therapy and CD8-Targeted Cytokines to Control B-Cell Lymphoma

A framework for optimal personalized neoAg vaccination in B-lymphoma is defined and it is demonstrated that neoAg vaccines can safely synergize with CD8+ T cell-selective immunotherapies to prevent T-cell dysfunction and generate durable systemic anti-tumor immunity.

Yuang Song, E. Aladyeva, Ruan F. Vieira Medrano et al. · 0 citations

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