Open access
Aug 2026
RNF213-dependent lytic destruction of Chlamydia-containing vacuoles activates host cell death pathways
The cytokine gamma-interferon (IFNγ) promotes antimicrobial cell-autonomous immunity by inducing hundreds of interferon-stimulated genes (ISGs). Among these ISGs is the ubiquitin E3 ligase RNF213 which protects host cells from a wide range of intracellular pathogens including the obligate intracellular bacterium Chlamy...
Mary S. Dickinson, Stephen C. Walsh, Robert J. Bastidas et al.
· Proceedings of the National... · 0 citations