A practical, solution-oriented synthesis of current bottlenecks across experimental and computational pipelines is provided, emerging strategies to overcome these limitations are highlighted, and a roadmap for community-driven protocol sharing, benchmarking, and integration across spatial and multi-omics modalities is...
Min-Yao Jhu, Max Minne, Zi-Liang Luo et al.· The Plant Cell· 0 citations
PEAgent provides a foundational resource for decoding cell-type-specific plant cis-regulatory logic and interpreting noncoding variation in plants, and distinguishes grass-conserved from lineage-specific regulatory sequences better than sequence conservation scores alone.
Jie Yao, Jiaqi Li, Xuan Zhang et al.· bioRxiv· 0 citations
Easy-Multiome, a streamlined single-cell multiomic workflow that integrates a single in situ reverse transcription step into the standard droplet-based scATAC-seq protocol, is presented, demonstrating that robust and efficient joint profiling of plant gene expression and chromatin accessibility while requiring only min...
Xuan Zhang, Mark A. A. Minow, Robert J. Schmitz· bioRxiv· 0 citations
ContextAware Significance of Cross-gene Attribution for Discovering Elements (CASCADE) is introduced, a positionspecific statistical framework for identifying model-derived candidate regulatory elements from in silico saturation mutagenesis and shifts motif recovery from downstream of the transcription start site towar...
Ali Farghadan, Robert J. Schmitz, Scott A. Jackson et al.· bioRxiv· 0 citations
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