Roberto Bello-Madruga

Seven amino acids gate transcriptional activation by a minimal MarA Helix-turn-helix DNA-binding domain

Prokaryotic transcription factors (TFs) lie at the core of antimicrobial resistance, controlling genes that let bacteria survive antibiotic exposure. The AraC/XylS family of TFs is defined by a ∼99-residue DNA-binding domain composed of two helix-turn-helix (HTH) motifs. While this two-motif architecture is considered...