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Author

Roberto Mallone

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2 papers indexed here

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Open access Sep 2026

Engineering the insulin signal peptide to protect human pancreatic beta cells from autoimmune destruction.

Beta cells expressing insulin with chromogranin-A signal peptide evaded recognition and killing by autoreactive T cells without inducing ER stress or compromising cellular identity, and may offer a targeted alternative to systemic immunosuppression to be used in stem-cell-derived therapies by engineering endogenous ins...

Farah Kobaisi, Masaya Oshima, Zhi-Cheng Zhou et al. · 0 citations
Open access Sep 2026

Going to the source: pancreatic lymph nodes maintain stem-like CD8+ T cells in human type 1 diabetes

Where does autoimmune persistence reside in type 1 diabetes (T1D)? Detailed investigation of the pancreas and pancreatic lymph nodes (PLNs) may provide more definitive answers, yet most studies in these target tissues have been confined to mouse models. In nonobese diabetic (NOD) mice, disease development is prevented...

Fatoumata Samassa, Sylvaine You, Roberto Mallone · 0 citations

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