Review
Aug 2026
Local energetic frustration: Protein evolution, conformational dynamics and design in the age of AI.
It is argued that incorporating frustration into computational and experimental strategies will be essential to move beyond purely stability-driven approaches toward the rational engineering of functional proteins.
Franco L. Simonetti, Eli J. Draizen, Rocío Espada et al.
· Biochimica et Biophysica Act... · 0 citations