Rodney E. Kellems

A self-sustaining hypoxia inducible factor-1α-creatine kinase B feedforward circuit drives macrophage-mediated kidney fibrosis.

INTRODUCTION A fundamental challenge in treating chronic kidney disease (CKD) is the lack of therapies to reverse established fibrosis. While systemic hypoxia sensors like erythrocyte sphingosine kinase 1 (eSPHK1) can initiate fibrotic signaling, the mechanisms driving self-perpetuating and progressive fibrosis remain...