Roger S. McIntyre

Transdiagnostic patterns of electroencephalography (EEG)-derived aperiodic activity across schizophrenia-spectrum, bipolar, and depressive disorders: A systematic review.

Aperiodic electroencephalographic activity is proposed as a scalable marker of cortical population dynamics relevant to excitation-inhibition balance. However, it remains unclear whether aperiodic parameters represent disorder-specific abnormalities or context-sensitive indices of clinically relevant brain states. Cons...

Cognitive effects of ketamine and esketamine treatment for major depressive and bipolar disorder: a systematic review.

BACKGROUND Cognitive impairment is a core feature of major depressive disorder (MDD) and bipolar disorder (BD). Most conventional antidepressants do not have direct and clinically relevant procognitive effects. Ketamine and esketamine are effective in treating treatment-resistant depression (TRD). Herein, this systemat...

A Systematic Review of Long-term Safety Outcomes of Ketamine and Esketamine in Patients with Treatment-resistant Depression.

Transitions in depressive symptom states among adults with subthreshold depression: Associations with lifetime trauma exposure and combined lifestyle in a multistate Markov study.

Lifetime trauma exposure was associated with lower recovery rates, whereas an unfavorable lifestyle was associated with lower recovery and higher worsening rates, which may inform trauma-informed assessment and lifestyle support for adults with subthreshold depression.