Author

Rohit Pal

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Open access Sep 2026

Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐Yl) Derivatives as EGFR Inhibitors Targeting EGFRWT , EGFRT790M , and EGFRL858R /T790M/C797S in NSCLC

A series of novel N‐Cinnamamide/benzamide‐(4‐(substituted phenyl)‐6‐(4‐cyclohexylphenyl)pyrimidin‐2‐yl) derivatives (Ri–Rxii) as EGFR inhibitors exhibited superior antiproliferative activity against wild‐type and mutant EGFR‐driven NSCLC cell lines, and was a strong candidate for overcoming drug resistance in NSCLC tre...

Rohit Pal, G. S. P. Matada, Ghanshyam Teli et al. · Chemical Biology and Drug De... · 0 citations

Aug 2026

Design, Synthesis, and Molecular Docking Studies of Coumarin-chalcone Conjugates as Selective TNF-α and Weak COX-2 Inhibitors with Efficacy as an Antioxidant.

INTRODUCTION Inflammation and oxidative stress play important roles in the development of various chronic diseases, necessitating compounds with dual therapeutic potential. METHODS A series of (E)-7-hydroxy-4-methyl-6-(3-(substituted phenyl)acryloyl)-2H-chromen-2-one (7a-m) were synthesized starting from 7-hydroxy-4-...

Dalaa Ali El-Jadayel, Husna Khalifa Al-Busaidi, Zainab Hamood Al-Balushi et al. · Anti-Inflammatory & Anti-All... · 0 citations