Author

Rohit Singh

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Open access Aug 2026

COMPASS: Component-Wise Inference of Shared and Gene-Specific Perturbation Response

Predicting how a genetic perturbation reshapes a cell’s transcriptome is a central goal of computational biology. Previous studies report that the mean response across training perturbations rivals specialized models on standard accuracy metrics, even though it cannot distinguish which perturbation occurred. Across 2,2...

Huan Liang, Rohit Singh · bioRxiv · 0 citations

Open access Jul 2026

Miniaturizing and modifying natural proteins with Raygun

Raygun is introduced, a generative artificial intelligence framework that enables miniaturization, modification and augmentation of proteins, using a probabilistic encoding of protein sequences constructed from language model embeddings, enabling the kind of coordinated, large-scale sequence modifications that characte...

Kapil Devkota, Daichi Shonai, Joey Mao et al. · Nature · 1 citation